ActiGraftPRO® System

A Regenerative Scaffold. A Personalized Approach.

The ActiGraftPRO® System transforms a small sample of the patient’s own blood into a whole blood clot — an autologous healing matrix that serves as a protective, regenerative scaffold at the wound site. Applied in minutes and compatible with clinical workflows, ActiGraftPRO supports the body’s natural healing processes for non-healing, exuding cutaneous wounds.

Why ActiGraftPRO?

• Workflow-Compatible
  No centrifuge. Just a 5-minute clot formation using simple, clinic-ready tools. Blood may be drawn and stored for up to 24 hours.

• Natural & Personalized Healing
  Supports wound closure using the patient’s own biological components — even in patients on blood thinners or with religious sensitivities.

• Reimbursable Under G0465
  Eligible for CMS coverage when used in diabetic chronic wounds per NCD 270.3.

• Non-Skin Substitute
  Clearly categorized as a blood-derived product — not a skin substitute or CTP.

• Adaptable Across Wound Sizes
  One 28.3 cm² clot can be used to treat wounds up to 56 cm².

How It Works

Reactivating the Healing Cascade
The ActiGraftPRO whole blood clot delivers red blood cells, macrophages, platelets, fibrin, clotting factors, and cytokines into the wound bed. This provisional matrix restores a functional healing environment and replaces the dysfunctional extracellular matrix that often stalls chronic wounds.

• Step 1: Blood draw (18–20 mL)

• Step 2: Mix with proprietary clotting components

• Step 3: Wait 5 minutes for clot formation

• Step 4: Apply directly to the wound bed

• Step 5: Repeat every 5–7 days until wound closure

Applications

Indicated for the management of exuding wounds such as:

• Diabetic foot ulcers (DFUs)

• Venous leg ulcers

• Pressure injuries

• Surgical or mechanically debrided wounds

ActiGraftPRO should be used in conjunction with standard-of-care practices, including offloading, compression therapy, wound bed preparation, and infection management.

System Components

Each kit includes all single-use tools required to prepare and apply the clot:

• Patient Phlebotomy System (blood draw needle, anticoagulant tube, transfer set)

• Coagulation System with kaolin and calcium gluconate

• Sterile application accessories (gloves, dressings, drape, mask, tape.)

Technical Specifications

• Clot Size: 28.3 cm²

• Diameter: ~6 cm

• Blood Volume Required: 18 mL

• Shelf Life: 2 years

• Storage: 5°C to 30°C